LRP6 and renal cell carcinoma: In our experiments, the expression of LRP5, LRP6, RYK and ROR2 were down regulated after the konckdown of FZD8 levels in 786O and A498 cells as shown in Figure 3, which indicate that FZD8 facilitate the RCC proliferation and metastasis is also dependant on the coreceptor of frizzled family members.