The knockdown of MET/FZD8 pathway in head and neck squamous carcinomas (HNSCC) diminishes the cancer stem-like cells (CSC) population and prohibits the progression and metastasis of HNSCC [32], FZD8 expression was found to be up-regulated in renal cell carcinoma, acute lymphoblastic leukemia and lung cancer, but the function of FZD8 in the development of RCC is poorly investigated [22, 62, 63]. Here, MET is linked to hereditary clear cell renal cell carcinoma.