In our experiments, the expression of LRP5, LRP6, RYK and ROR2 were down regulated after the konckdown of FZD8 levels in 786O and A498 cells as shown in Figure 3, which indicate that FZD8 facilitate the RCC proliferation and metastasis is also dependant on the coreceptor of frizzled family members. This evidence concerns the gene LRP5 and renal cell carcinoma.