MET increased the expression of FZD8 via the ERK/c-Fos cascade in the cancer stem-like cells (CSC) of head and neck squamous carcinomas (HNSCC), and Wnt pathway receptor FZD8 was necessary for interplay between MET and Wnt/β-catenin signaling. The gene discussed is FZD8; the disease is head and neck squamous cell carcinoma.