The knockdown of MET/FZD8 pathway in head and neck squamous carcinomas (HNSCC) diminishes the cancer stem-like cells (CSC) population and prohibits the progression and metastasis of HNSCC [32], FZD8 expression was found to be up-regulated in renal cell carcinoma, acute lymphoblastic leukemia and lung cancer, but the function of FZD8 in the development of RCC is poorly investigated [22, 62, 63]. The gene discussed is MET; the disease is acute lymphoblastic leukemia.