ADNFLE is a genetically heterogeneous condition, and the roles of genes encoding subunits of neuronal acetylcholine receptors (nAChRs), such as 4, 2, and 2 (CHRNA4, CHRNA2, and CHRNB2), have been clearly established in ADNFLE [4, 5]. Here, CHRNA2 is linked to autosomal dominant nocturnal frontal lobe epilepsy.