NEDD8 and breast carcinoma: The results of the proteomic analysis of ibrutinib treated OCI-LY10 tumours demonstrated a significant increase in the levels of a number of proteins inlcuding dermicidin, a pro-survival factor previously linked to an oncogenic function in breast cancer [24], as well a reduction in NEDD8, a small molecule akin to ubiquitin and required in the process of neddylation [25].