TERT promoter mutations occur frequently in a number of other cancers: 80–90% of glioblastoma multiforme, 60% of hepatocellular carcinoma, 60% of bladder cancer, 70% of basal cell carcinoma, 50% of cutaneous squamous cell carcinoma and up to 30% of thyroid cancers [6-11] and are associated with aggressive disease in thyroid carcinoma [12], glioblastoma [13], neuroblastoma [14] and renal cell carcinoma [15]. The gene discussed is TERT; the disease is hepatocellular carcinoma.