MAT1A and familial pancreatic carcinoma: We next examined whether SAMe, MTA and miR-34a/b influence the expression of these MAT genes and proteins in 22Rv-1 (human prostate cancer cell line) and MIA PaCa-2 (human pancreatic cancer cell line), which express moderate levels of these proteins as compared to multiple other prostate and pancreatic cancer cell lines (Figure 7).