Subsequent multivariate analysis results revealed that high PVT1 expression (HR: 2.539, P <0.001) and low HAR1A expression (HR: 1/0.625=1.6, P = 0.021) were the independent prognosis factors for survival of glioma patients, in addition to increased age, high KPS and grade. This evidence concerns the gene PVT1 and central nervous system cancer.