Moreover, the independent glioma RNAseq data from TCGA was employed to perform further analysis, and we found that the expressions of PVT1 and CYTOR were noticeably higher in GBM samples than in lower grade gliomas (LGGs, all P <0.001; Figure 2B) that refer to some diffuse glioma subtypes including astrocytoma, oligodendroglioma and oligoastrocytoma (OA). This evidence concerns the gene PVT1 and glioblastoma.