EIF2S1 and breast carcinoma: Moreover, both the EIF2 (through the activation of the PI3K pathway) and 14-3-3-mediated signaling cascades regulate the mTOR pathway [125, 126], which is involved in the response to hormones and growth factor stimulation and is well known to exert a significant role in tumor cell growth and proliferation as well as in breast cancer development [127] and references therein.