The oncogenes, SRC is the most important intersection point, so we inhibited the expression of PLAGL2 and POFUT1 in SW620 cells.The results found that low-expression of SRC can be found in two knockout cells (Figure 8B), which indicate PLAGL2 and POFUT1 cooperatively participate in SRC biological pathways, and therefore promote pathogenesis and development of colorectal cancer. This evidence concerns the gene PLAGL2 and colorectal cancer.