TM9SF4 and colorectal adenocarcinoma: Recent studies have confirmed that several of the 6 genes discussed above are involved in human cancer, especially colorectal cancer., TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells [16], PLAGL2 induces epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human colorectal adenocarcinoma [27] and overexpression of protein POUT1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway [28].