We found that these overexpressed adjacent genes caused by CNA in colorectal cancer can cooperatively participate in the same biological pathways associated with human cancers, including colorectal cancer.Additionally, we inhibited the expression of PLAGL2 and POFUT1 in SW620 cells by shRNA, the result found that PLAGL2 and POFUT1 both can be involved in SRC biological pathways. This evidence concerns the gene POFUT1 and colorectal cancer.