Jin et al found that heavy smokers (>20 pack-years) carrying XRCC1 rs25487 GG genotype had significantly lower PFS rates than others in the 75 patients with NPC at stage II-IVA-B (HR=2.019, 95%CI: 1.010-4.036, P=0.047) [25]. The gene discussed is XRCC1; the disease is nasopharyngeal carcinoma.