Alsbeih et al analyzed the association between XRCC1 rs25487 (g.G28152A) and the late reaction to radiotherapy in 60 NPC patients, and found that XRCC1 g.28152A allele was significantly associated with a lower grade condition of grade ≥2 skin and deep tissue fibrosis (OR=0.30, 95%CI: 0.10-0.89, P=0.02) [28]. The gene discussed is XRCC1; the disease is nasopharyngeal carcinoma.