We recently reported that increased production of C-C motif chemokine 2 (CCL2) due to downregulation of F-box and WD repeat domain containing 7 (FBXW7) in bone marrow (BM)-derived stromal cells promoted the formation of premetastatic niches through recruitment of myelo-monocytic cell-derived suppressor cells and TAMs, thereby promoting metastatic tumor growth [6]. This evidence concerns the gene FBXW7 and neoplasm.