CXCL12 and prostate carcinoma: For example, overexpression of RGS1 suppresses CXCL12-mediated migration in human plasmacytoma cells [22], epigenetic repression of RGS2 is related with the development of prostate cancer [23], overexpression of RGS5 plays an inhibitory role in human lung cancer cells through induction of apoptosis [24] and overexpression of RGS17 increased growth rate through the cyclic AMP-PKA-CREB pathway in lung tumor cells [25].