Functional silencing of IGFBP3 in prostate cancer epithelial cells resulted in increased E-cadherin, while neither of the transcriptional repressors, Snail or ZEB1 mRNA expression was significantly affected (by IGFBP3 knockdown) begging the question as to its role in EMT-MET cycling. The gene discussed is IGFBP3; the disease is Familial prostate cancer.