The differences in the response of CAFs from patient 2 vs patient 9 to DZ-50, as well as the differential IGFBP3 mRNA expression among the six prostate tumors (from individual patients), could be driven by the stroma and tumor heterogeneity that characterizes prostate tumors and the microenvironment [52, 53]. The gene discussed is IGFBP3; the disease is prostate neoplasm.