TGFB1 and Familial prostate cancer: Taking control of the dynamics of prostate stroma microenvironment is the multifunctional cytokine transforming growth factor-β1 (TGF-β1); activation of TGF-β1 signaling mediates the transition of fibroblast to myofibroblasts [14] and promotes prostate cancer cell-mediated differentiation of normal fibroblasts into CAFs towards metastasis [13, 15].