In this study, we demonstrated that HO-1 protein expression was positively correlated with International Prognostic Index (IPI) classification of ABC-DLBCL patients, and silencing HO-1 gene expression induced apoptosis and arrested cell cycle in the G0/G1 phase in ABC-DLBCL cell line LY-10 after SAHA treatment. Here, HMOX1 is linked to aneurysmal bone cyst.