Metapristone could induce significant cell apoptosis via targeting EGFR and its downstream PTEN/AKT and ERKs signaling pathways by up-regulating the level of PTEN, and down-regulating the expression of P-AKT and P-ERK proteins, as well as activating the apoptotic-related proteins caspase-3 in NSCLC cells. This evidence concerns the gene EGFR and non-small cell lung carcinoma.