However, inhibiting either pathway by RNAi against Dronc, Death-associated APAF1-related killer (Dark), Atg1, Atg7 or Atg18, or by overexpression of the caspase inhibitor P35 (UAS-P35), had no significant negative effect on upd3-lacZ levels during infection (S7B Fig). The gene discussed is WIPI1; the disease is infection.