CD101 is expressed on CD4+ and CD8+ T-cells, dendritic cells and monocytes, [39] and appears to alter CD4+/CD25+/FOXP3+ T regulatory cell (Treg) function based on both a murine graft-versus-host disease model [40], and through IL10 secretion from human dendritic cells [41]. The gene discussed is IL10; the disease is graft versus host disease.