SLCO1B3 and spindle cell hemangioma: In current studies, we found that treatment with the lysosome inhibitor chloroquine markedly increased the total protein levels of OATP1B3 not only in the HEK293-OATP1B3 stable cell line (Fig 4A), but also in human SCH (Fig 4B), suggesting that the lysosome is also involved in the degradation of OATP1B3.