It has been recently reported that 60% of the anti-PF4/heparin antibodies that induced platelet activation in the presence of heparin also caused platelet activation in the presence of nucleic acids [12, 15] which suggests that only some aspects of ON-induced thrombocytopenia may be related to mechanisms leading to HIT and more research is required to delineate this effect. The gene discussed is PF4; the disease is Thrombocytopenia.