During T, HF nu was higher in C1-INH-HAE patients than in controls with lower variation of HF (23.0±18.4 vs 13.2±12.1, p = 0.05 and -3.3±16.7 vs -18.4±17.2, p<0.01 respectively) (Table 2). The gene discussed is SERPING1; the disease is hydrops fetalis.