Differential expression analysis between tumors with and without LOH confirmed an increase of PD-L1 and effector molecules such as granzymes-A, -B, and -H, as well as STAT1 and interferon (IFN)-γ, in lung adenocarcinoma with HLA LOH but not lung squamous cell carcinoma (Table S1). Here, CD274 is linked to lung adenocarcinoma.