To further address this point, we performed the 2‐month oral tolerance regimen, using lyophilized lettuce (CTB‐FVIII‐HC and CTB‐FVIII‐C2 mixture, 0.5 μg/antigen/dose), in haemophilia A mice with pre‐existing inhibitors (average titre of 28 BU, n = 13). The gene discussed is F8; the disease is hemophilia A.