HK2 and cancer: For example, lncRNA NRCP functions as an intermediate binding partner between STAT1 and RNA polymerase II, facilitating the transactivation of downstream target genes, involved in cancer glucose metabolism.30 Another finding showed lncRNA UCA1 promotes cancer cell glycolysis through the mTOR-STAT3/microRNA143-HK2 signaling axis.31 Equally, much attention has been focused on the regulation of cancer cell stemness by lncRNAs.