PRKAA1 and cancer: We previously identified a role for NUAK1 in supporting viability of cancer cells when MYC is overexpressed.21 Briefly, we showed that MYC-overexpressing cells are unable to maintain energetic homoeostasis in the absence of NUAK1, in part due to a failure to efficiently activate AMPK and slow TORC1-dependent protein translation when faced with metabolic stress.