The hallmark pathological lesions in the Alzheimer's disease (AD) brain are composed of amyloid beta (Aβ) peptides and phosphorylated tau protein, which lead to formation and deposits of extracellular Aβ plaques and intracellular neurofibrillary tangles, respectively (Giannopoulos & Pratico, 2015a). This evidence concerns the gene MAPT and Alzheimer disease.