To determine if PEDF also plays a role in the exosome-mediated inhibition of metastasis, we assessed the PEDF levels in exosomes harvested from melanoma lines with forced (A375-PEDF, B16F10-PEDF) or endogenous (sBCL2, C81-61-PA)47 PEDF expression and from their metastatic counterparts (A375, B16F10, C8161-HA). The gene discussed is SERPINF1; the disease is melanoma.