Importantly, it has been shown that quercetinsupplementation in an animal model reduced insulinresistance and improved therapeutic effects in PCOS rats.Also, it was demonstrated that mechanistically quercetininhibits the Toll-like receptor/NF-κB signaling pathwayand in turn enhances the inflammatory microenvironmentof the ovarian tissue of the PCOS rat model (39). This evidence concerns the gene NFKB1 and polycystic ovary syndrome.