In this context, the positivecorrelation of ADIPOR1 and ADIPOR2 and serum AMPKoverexpression suggests that quercetin supplementationexerts its beneficial metabolic effects in PCOS patientsby targeting adiponectin and AMPK signaling pathways.While these three molecules are expressed in the ovary,it is reasonable to examine the biological actions of fuelsensors in fertility and it importance in fertility problems(2). This evidence concerns the gene ADIPOR2 and polycystic ovary syndrome.