For example, migration of prostate cancer cell could be induced by CXCL12/CXCR4 activation through Akt‐1 and MMP‐9 signaling pathway and migration of pancreatic cancer cells is modulated through MMP‐2 and MMP‐9 pathway 33, 34. Here, CXCR4 is linked to familial pancreatic carcinoma.