It is worrying that a higher chance to be born large for gestational age is reported as an outcome for insulin therapy [92] or in pregnant women treated with insulin and metformin [93] and in a larger number (~25%) of infants showing one or more episodes with neonatal morbidity where neonatal asymptomatic hypoglycaemia was the most frequent [94]. The gene discussed is INS; the disease is Hypoglycemia.