IGHE and eosinophilic esophagitis: It is clear from clinical experimental data that EoE is not a typical, purely IgE-mediated disease; rather, one sees characteristics of EoE found in hypersensitivity reactions, in mostly T cell-mediated skin diseases, e. g., allergic contact dermatitis, drug eruptions, atopic dermatitis triggered by food, or chronic inflammatory bowel diseases [42].