DCs were also modified with genetic constructs: namely, adenoviral vectorsencoding TAAs (colorectal cancer [48],hepatocellular carcinoma [49], and Lewislung carcinoma [58]) or mRNA encodingfusion polypeptide β2m-tumor peptide-TLR4 containing TAA linkedto the components of both MHC I and the Toll-like receptor TLR4 (B16 melanoma[55]). The gene discussed is TLR4; the disease is hepatocellular carcinoma.