Many remissions were observed in patients with melanoma after they had receivedDC-based vaccines loaded with a mixture of mRNAs encoding TAAs MAGE-A1,-A3,-C2,tyrosinase, MelanA/MART-1 and gp100 fused with HLA II-targeting sequences, incombination with IFN-α-2b injections [77]. Here, PMEL is linked to melanoma.