Specifically, the SAPPHIRE study assessed the urine product of TIMP-2 and IGFBP-7 and concluded that it is superior in the prediction of KDIGO stage 2-3 AKI compared with the rest of the biomarkers of the study, even NGAL and KIM-1 (p < 0.002) in critically ill patients [80]. This evidence concerns the gene IGFBP7 and acute kidney injury.