In AKI, apart from hypoxia, the increased ROS production due to inflammation and oxidative stress causes mitochondrial depolarization and dysfunction that through the PINK1/Parkin (PTEN-induced putative kinase protein 1) and the BNIP3/NIX/FUNDC1 pathway lead to selective mitochondrial autophagy (“mitophagy”) [24, 44]. Here, PINK1 is linked to acute kidney injury.