However, low expression of miR-34a was noted in other types of cancer [46, 51–54], in glioblastoma and glioma with mutant Tp53 [55], in chronic lymphocytic lymphoma with Tp53 deletion [56], and in metastatic hepatocellular carcinoma [57], reflecting that miRNA-34a can work in a cell type-specific manner with a differential p53 pathway inactivation [36]. The gene discussed is TP53; the disease is central nervous system cancer.