Induction of Notch1 transformed high-grade adenoma into low-grade adenoma in an APCMin mouse model of colon cancer and suppressed the expression of Wnt target genes through epigenetic modification connected with recruitment of histone metylotransferase SET domain bifurcated 1 (SETDB1) [70]. The gene discussed is SETDB1; the disease is malignant colon neoplasm.