Although, NF-κB activation is not a pre-requisite for tumor, but it plays an important role in moderating inflammation, setting up the tumor microenvironment and stimulating immunomodulatory cells including, pro and anti-inflammatory cytokines, and chemokine production (Mantovani et al., 2008, 2010; Grivennikov et al., 2010). This evidence concerns the gene NFKB1 and neoplasm.