FMRP loss in Fmr1−/y mice has been shown to cause abnormal synaptic and structural plasticity in CA1 pyramidal cells (Huber et al., 2002; Lauterborn et al., 2007; Hu et al., 2008; Meredith and Mansvelder, 2010; Busquets-Garcia et al., 2013), which in turn have been associated with impaired hippocampal function as well as cognitive deficits (Contractor et al., 2015; Radwan et al., 2016). The gene discussed is FMR1; the disease is Cognitive impairment.