In pre-symptomatic SOD1(G86R) ALS mice, despite more glucose consumption, a metabolic switch toward lipid use was found in fast-twitch muscles, possibly due to the inhibition of pyruvate dehydrogenase (PDH), a pivotal enzyme of carbohydrate catabolism (Kioumourtzoglou et al., 2015). The gene discussed is PDP1; the disease is amyotrophic lateral sclerosis.