GAPDH and amyotrophic lateral sclerosis: In order to determine if the potential defects in glucose uptake, suggested by (1) a glucose intolerance, (2) a decrease in lactate output and (3) defects in muscular GLUT4 expression, would impact glycolysis in ALS muscles, we analyzed the expression pattern of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH).