SOD1 and amyotrophic lateral sclerosis: ALS-induced glucose intolerance, albeit well established in human ALS patients (Poulton and Rossi, 1993; Pradat et al., 2010), was not found in previous studies using male SOD1(G86R) ALS mice, in which an increase in glucose tolerance was revealed (Dupuis et al., 2004b) or in a mix of male and female SOD1(G93A) ALS mice, in which no alteration of glucose tolerance could be recorded (Smittkamp et al., 2014).