MAP1LC3B and amyotrophic lateral sclerosis: Here, we compared the expression of autophagy markers in two muscles that are known to be differentially affected by the disease, i.e., the relatively spared soleus vs. the highly affected tibialis. We found a dramatic accumulation (more than fivefold) of the main autophagy protein LC3B, whatever the form I or II, in the ALS tibialis whereas this accumulation was less than twofold in the ALS soleus, and only concerned LC3B II.