ALS-induced glucose intolerance, albeit well established in human ALS patients (Poulton and Rossi, 1993; Pradat et al., 2010), was not found in previous studies using male SOD1(G86R) ALS mice, in which an increase in glucose tolerance was revealed (Dupuis et al., 2004b) or in a mix of male and female SOD1(G93A) ALS mice, in which no alteration of glucose tolerance could be recorded (Smittkamp et al., 2014). This evidence concerns the gene SOD1 and Glucose intolerance.