For all three combinations (iNOS/Arg1, p = 0.0406, iNOS/CD206, p = 0.0401, and iNOS/Ym1, p = 0.054), M1/M2 ratios were decreased following i.c.v. injection of OPN into stroke rats (Figure 1(b)). The gene discussed is NOS2; the disease is stroke disorder.