For example, a multi-region sequencing analysis identified inactivation of Polybromo 1 (PBRM1), a component of the SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complex, as a truncal event in several renal cell carcinoma cases [119]. Here, PBRM1 is linked to hereditary clear cell renal cell carcinoma.