In a study that assessed the involvement of MsrA, SIRT1 and RVT in PD, Wu and collaborators demonstrated that phytoalexin was able to enhance the resistance of human neuroblastoma SH-SY5Y cells to 1-methyl-4-phenylpyridinium ion (MPP+)-induced neurotoxicity and that it upregulates MsrA expression. This evidence concerns the gene SIRT1 and Parkinson disease.