For this reason, our aim was to analyze, in the Spanish Mediterranean population (which was not included in previous GWASs), the association of the most relevant polymorphisms discovered in the first GWAS carried out on various populations (including the loci TMCO1, CAV1/CAV2 and CDKN2A and CDKN2B-AS1) [10,12] with POAG risk in this population. This evidence concerns the gene CAV1 and open-angle glaucoma.