To identify potential genetics factors in the etiology DD and LD, we performed WES on three family members heterozygous for the LMNA mutation and affected with cardiac disease, DD and/or LD (III-4, IV-3 and Patient 3) and one unaffected family member without the LMNA mutation and unaffected with cardiac disease, DD and LD (IV-1). Here, LMNA is linked to heart disorder.