Since Lamin A/C haploinsufficiency may disrupt biological processes also important in the etiology of fibromatosis including cell differentiation, gene expression, and signaling pathways, additional defects in these processes due to ASTE1 c.230T>C (p.Val77Ala) may lead to susceptibility for fibrotic disease in LMNA heterozygotes. This evidence concerns the gene ASTE1 and fibromatosis.