With the possible role of ASTE1 in EGFR signaling [33], the complex pathway with significant roles in cell–cell communication, cell fate, and proliferation [38], our findings raise the possibility that ASTE1 c.230T>C (p.Val77Ala) may result in susceptibility to palmar and plantar fibromatosis in our family. This evidence concerns the gene ASTE1 and plantar fibromatosis.