Regarding modulation of cannabinoid-related enzymes, the inhibition of FAAH (via the selective FAAH inhibitor URB597) was shown to result in a reduced expression of inflammatory mediators in rat cortical microglia, using an LPS-induced sepsis model [61] and similarly decreased levels of TNFα and IL-1β in an LPS-induced pain model in rats [62]. This evidence concerns the gene FAAH and Sepsis.