Figure 3 shows the melting and sequencing results from three of the patients. In this figure, Patients 1 and 3, but not Patient 4, have an R201 mutation. Of the six samples, three (Patients 1–3) from patients with more severe symptoms (having both precocious puberty and FD) had a mutant GNAS. Clinical features of Patient 1 are shown in Supplemental Figure S1. The other three (Patient 4–6) from patients with mild symptoms (only having FD) showed wild-type results (Table 1 and Supplemental Figure S2). Here, GNAS is linked to Fabry disease.