Since time-intensified CHOP is advantageous for the treatment of high-grade non-Hodgkin’s lymphoma in elderly patients (Pfreundschuh et al. 2004a; Roesch et al. 2014; Rosch et al. 2016), we designed a regimen with six cycles of CHOP repeated every 12 days (CHOP-12). The gene discussed is DDIT3; the disease is non-Hodgkin lymphoma.