INS and obesity due to melanocortin 4 receptor deficiency: This is in accordance with adult data from the DCCT trial, where patients with T1DM who received the higher insulin doses also had increased weight gain and higher total cholesterol and LDL-C, central obesity, insulin resistance, blood pressure, more coronary artery calcifications, and higher CIMT on follow-up, underlying the role of obesity in promoting CVD in patients with T1DM [49].