EGFR and prostate carcinoma: PSMA was also shown to facilitate integrin signaling and p21-activated kinase activation, leading to both productive invasion and downregulation of beta1-integrin (a cell-matrix linker), to induce chromosomal instability, to play a VEGF-independent role in neoangiogenesis and to recruit a functionally active complex present in high grade prostate carcinoma patients associated with EGFR phosphorylation [23–26].