As shown previously by Lapidus et al., using a N-acetylaspartylglutamate (NAAG) hydrolytic radioenzymatic assay to quantify the enzymatic activity of PSMA in normal, benign prostate hyperplasia (BPH) and prostate cancer tissues from radical prostatectomies, PSMA enzyme activity proved significantly elevated in prostate cancer when compared to normal prostate tissues and BPH [22]. This evidence concerns the gene FOLH1 and Familial prostate cancer.