Our study hypothesis was that more aggressive disease characteristics (higher Gleason score and PSA levels) will be seen in Black South-Africans compared with White South-Africans with treatment-naïve prostate cancer, and that these characteristics will correlate positively with PSMA uptake in the primary tumor and presence of distant metastases on 68Ga-PSMA-11 PET/CT. Here, FOLH1 is linked to Familial prostate cancer.