We have therefore investigated the longitudinal course of BP and markers of systemic and vascular inflammation and endothelial dysfunction (CRP, soluble intracellular adhesion molecule-1 [sICAM-1], soluble vascular cellular adhesion molecule-1 [sVCAM-1], and soluble E-selectin [sE-selectin]) and their temporal inter-relationships, in a cohort of individuals with type 1 diabetes who were followed over 20 years, since the onset of disease. This evidence concerns the gene SELE and endothelial dysfunction.