ACVR2A and neoplasm: By searching for differentially expressed kinases between the different Kinobeads Subtypes using SAM (median FDR of 0.01), we identified proteins frequently mutated in microsatellite instable (MSI+) tumours with concomitant decrease in expression of proteins such as ACVR2A and TGFBR2 (Kim et al, 2013), as well as the receptor tyrosine kinase EPHA2, which was overexpressed in KC (Table EV4).