A genome-wide association study of IgG4-RD, for example, has been performed in a Japanese population (Terao et al. International Symposium of IgG4-RD and Fibrosis, Feb 2017), and this reported three susceptibility loci consistent with antigen-driven disease: HLA-DRB1, HLA-A and FCGR2B, the latter encoding a low affinity receptor for IgG. This evidence concerns the gene HLA-DRB1 and immunoglobulin G4-related sclerosing disease.