PTX3 and pulmonary fibrosis: Similarly, the collectin Pentraxin 3 can both be produced in lung endothelial cells in response to IL-1 (Pauwels et al., 2010) or in lung fibroblasts in response to TNF-α (Mantovani et al., 2013) and is associated with pulmonary fibrosis (Pilling et al., 2015).